The calendar has flipped to March, and you know what that means: pure, unadulterated basketball chaos is upon us. The 2026 NCAA Men's Basketball Tournament is set to explode onto screens this Thursday and Friday with a staggering 32 first-round games. While the top seeds will command attention, the real magic of March Madness lies in the bracket-busting upsets that leave fans in shock. But which underdogs have the best shot at making history right out of the gate?

According to the number-crunching wizards at ESPN, we might not have to wait long for the madness to begin. Their proprietary Basketball Power Index (BPI)—a sophisticated projection system designed to be the ultimate predictor of future performance—has run the simulations and pinpointed three first-round games where the lower seed has a compelling chance to win.

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The BPI's Top Three Upset Picks

So, which Cinderellas are getting the digital nod? The model highlights a trio of matchups where the underdog could spoil some early tournament dreams:

  • No. 10 Texas A&M over No. 7 St. Mary's
  • No. 10 Missouri over No. 7 Miami
  • No. 11 VCU over No. 6 North Carolina

These potential 10-over-7 and 11-over-6 victories are the bread and butter of an unpredictable tournament. But the BPI didn't stop there. It also flagged the single most likely "big-time" upset of the opening round: a potential stunner where the No. 12 seed High Point Panthers could topple the No. 5 seed Wisconsin Badgers. That game is scheduled for a 1:50 p.m. ET tip-off on Thursday, so set your alerts.

How Does ESPN's Computer See the Future?

You might be wondering how a computer model can possibly account for the pressure-cooker environment of March. The BPI is far from a simple ranking. It's a projection-based system that evaluates team strength by measuring how many points above or below average a squad performs. The model doesn't just look at wins and losses; it digs deep into the context of those results through a metric called Strength of Record (SOR).

When forecasting individual games, the BPI considers a dizzying array of factors: opponent strength, pace of play, home-court advantage (or neutral-site nuances), travel distance, rest between games, and even altitude. It then simulates the season an astonishing 10,000 times to produce its projections, which update daily. For a deeper dive into how these models shape the tournament conversation, check out our analysis on ESPN's final BPI Top 25 rankings.

While the computers are buzzing, the human element always has the final say. The NCAA selection committee itself has faced scrutiny this year, with some analysts pointing out perceived flaws in the bracket. For a different perspective on the tournament setup, read about the major bracket blunders critics have identified.

Of course, predictions are just that—predictions. The beauty of March Madness is that anything can happen once the ball is tipped. A hot shooter, a key injury, or a single controversial call can render even the most advanced algorithm obsolete. That's why we watch. For those looking to experience the pandemonium in person, you can score $20 off March Madness tickets with this special code.

As the tournament unfolds, all eyes will be on these highlighted matchups. Will the BPI's cold, hard logic prove correct, or will the unpredictable heart of college basketball deliver a completely different set of surprises? One thing is certain: from Thursday morning until the final buzzer in April, expect the unexpected. It's the only guarantee March provides.