The San Francisco 49ers' nightmare injury luck has struck again. Rookie wide receiver De'Zhaun Stribling, the team's first-round pick, went down with a devastating ankle injury during Thursday's season opener against the Los Angeles Rams — and the football world is collectively holding its breath.

Stribling, who lit up the preseason with seven catches for 63 yards in his debut, was making his regular-season bow at Levi's Stadium. But early in the first quarter, he hobbled to the medical tent after appearing to tweak something. He tried to gut it out and return, showing the kind of toughness that made him a fan favorite in Santa Clara.

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Then, in the second quarter, the worst possible scenario unfolded. Stribling crumpled to the turf on a non-contact play, grabbing at his lower leg. The look on his face said it all. As trainers rushed out, the stadium went quiet. He needed help getting to the sideline, and soon after, reports confirmed he was carted to the locker room.

The replay, shown on the broadcast, was hard to watch. Social media erupted almost instantly, with NFL fans flooding X (formerly Twitter) to send their support.

“You can just tell that’s bad,” one fan wrote. “Prayers up man.”

“Prayers for Stribling,” added another. “Man you hate to see that.”

“Stribling non-contact??? You can’t make this up,” a third fan posted.

The sentiment was echoed by a fourth: “Dezhaun Stribling looked so promising in the preseason smh Of course he’d get injured 1st game.”

For a 49ers team that has been ravaged by injuries in recent years, this is a gut punch. Stribling was expected to be a key piece in Kyle Shanahan's offense, a reliable target with electric speed and sure hands. His loss would be a significant blow to a receiving corps already dealing with its share of issues.

As of now, the official diagnosis hasn't been announced, but the fact that he needed a cart in Melbourne — the game was played at the MCG as part of the NFL's international series — doesn't bode well. The Ole Miss product faces an uncertain future, and fans are left hoping for a miracle.

This isn't the first time this season that a promising young player has gone down in heartbreaking fashion. Just last week, Sam Darnold suffered a gruesome leg injury that left Seahawks fans sick. And the broader conversation about player safety has been reignited, with some calling for overhauls in other sports to prevent injury epidemics.

For now, all we can do is wait. The 49ers will provide an update in the coming days, but the early signs are ominous. Stribling's rookie season may be over before it truly began, and that's a tough pill to swallow for a player who worked his entire life for this moment.

Our thoughts are with De'Zhaun Stribling. Here's hoping for some positive news this weekend.